Single-variant meta-analysis identified two loci associated with WL in COPD: five variants within DRAIC in the B/AA meta-analysis (lead variant chr15:69571341:A:G, OR (CI<sub>95</sub>) = 1.37(1.23-1.51), p = 1.29 × 10<sup>-9</sup>) and two intronic variants within RFX3 in the cosmopolitan meta-analysis (lead variant chr9:3390983:T:C, OR (CI<sub>95</sub>) = 1.50(1.31-1.73), p = 1.06 × 10<sup>-8</sup>). The gene discussed is RFX3; the disease is chronic obstructive pulmonary disease.