Our analysis confirms a role for the filaggrin (FLG) gene, with meta-analysis revealing associations between FLG loss-of-function (LOF) mutations and AD (OR 2.426, 95% CI 1.890-3.114) in cohort studies and (OR 4.44, 95% CI 2.42-8.12) in case-control studies, asthma (OR 1.90, 95% CI 1.33-2.71), and food allergy (OR 1.79, 95% CI 1.11-2.88) in cohort studies. The gene discussed is FLG; the disease is asthma.