This study aimed to evaluate epiplakin expression in cutaneous skin lesions and to investigate its association with epithelial-mesenchymal transition markers and tumor progression.<h4>Methods</h4>The authors retrospectively analyzed skin specimens from squamous cell carcinomas, basal cell carcinomas, and benign intradermal nevi collected between 2021 and 2025. The gene discussed is EPPK1; the disease is basal cell carcinoma.