PURPOSE: To evaluate amide proton transfer chemical exchange saturation transfer magnetization transfer ratio asymmetry (MTRasym) and arterial spin labeling cerebral blood flow (CBF), two advanced MRI-based maps, for predicting glioma isocitrate dehydrogenase (IDH) mutation status, 1p/19q codeletion status, and grade using radiomics features; to assess cross-dataset/cross-vendor generalizability; and to examine whether combining MTRasym and CBF features improves prediction. The gene discussed is IDH3A; the disease is central nervous system cancer.