This study aims to investigate the influence of the COVID-19 pandemic on the epidemiology and clinical outcomes of MP infection among hospitalized pediatric CAP patients in Ganzhou, China.<h4>Methods</h4>We retrospectively analyzed 27,369 hospitalized pediatric CAP patients (2017-2024), comparing MP positivity, seasonality, age distribution, and severity across pre-pandemic, NPIs, and post-NPIs phases.<h4>Results</h4>Among 27,369 CAP patients, 3,334 were MP-positive (12.18%). The gene discussed is PPP1CB; the disease is COVID-19.