Transcriptomics identified that TSLP upregulated pro-inflammatory pathways in macrophages, including positive regulation of cytokine production, regulation of immune effector process, cytokine-cytokine receptor interaction and chemokine signaling pathway.<h4>Conclusions</h4>Our integrated multi-level analysis has identified TSLP as a novel pathogenic driver of AAA, which promotes disease progression by reprogramming macrophage polarization. Here, TSLP is linked to triple-A syndrome.