The present study aimed to evaluate the association of preoperative NLR and CRP levels with the severity of calculous cholecystitis and their relationship with clinical outcomes.<h4>Materials and methods</h4>This prospective observational study was conducted over two years in a tertiary care centre and included 48 patients diagnosed with cholelithiasis with cholecystitis and undergoing laparoscopic cholecystectomy. Here, CRP is linked to cholelithiasis.