Based on the multivariable results, a nomogram prediction model was constructed using R version 4.2.1, and its discriminatory ability was evaluated by the area under the receiver operating characteristic curve (AUC).<h4>Results</h4>Multivariable logistic regression analysis showed that low body mass index (BMI) (OR = 0.654, 95% CI 0.488-0.877, <i>p</i> = 0.005), low CD4<sup>+</sup> T-lymphocyte count (OR = 0.990, 95% CI 0.981-0.999, <i>p</i> = 0.031), and low serum albumin level (OR = 0.795, 95% CI 0.689-0.919, <i>p</i> = 0.002) were nutritional risk factors in AIDS patients. The gene discussed is CD4; the disease is AIDS.