The multivariate logistic analysis indicated that family history, Ki67, and rs2277438 were positively correlated with bone metastasis, but menopausal state, clinical staging, and rs7325635 were negatively correlated with bone metastasis in breast cancer.<h4>Conclusion</h4>The <i>RANKL</i> rs2277438 variant may be a potential genetic susceptibility factor associated with bone metastasis risk in breast cancer patients, though further functional validation is warranted. The gene discussed is TNFSF11; the disease is metastasis.