IGHE and chronic rhinosinusitis: <h4>Background</h4>The presence of IgE autoantibodies against human proteins ("autoallergy") has been identified in different type 2 inflammation.<h4>Objective</h4>The aim of this study was to evaluate the presence of autoallergy in chronic rhinosinusitis (CRS) and explore its clinical impact.<h4>Methods</h4>Cross-sectional study with CRS patients and healthy controls.