Transcriptomic profiling of TCGA datasets revealed significant up-regulation of CUL1, CUL2, CUL4A, CUL4B, CUL5, CUL7, and CUL9 in tumor tissues, with higher expression correlating with advanced stage and poorer survival, particularly for CUL5 and CUL7. This evidence concerns the gene CUL7 and neoplasm.