SPP1 and hepatocellular carcinoma: In vitro, SPP1 was knocked down or overexpressed in HCC cell lines to evaluate effects on proliferation, migration, invasion, and apoptosis via qRT-PCR, Western blot, CCK-8, colony formation, wound healing, Transwell invasion, and TUNEL assays.<h4>Results</h4>SPP1 was significantly upregulated in HCC at mRNA and protein levels.