Crucially, YHY treatment inhibited METTL3 expression and m6A methylation levels, leading to decreased mTOR mRNA stability and protein expression, which subsequently restored autophagic activity.<h4>Conclusion</h4>YHY, a traditional Chinese medicine formula with defined chemical metabolites, ameliorates podocyte damage in DN by activating autophagy via the METTL3-m6A-mTOR signaling pathway. Here, METTL3 is linked to liver dysplastic nodule.