In vivo experiments confirmed that BJJP effectively ameliorated liver function-related biochemical indices and histopathological alterations in mice with HF, downregulated the expression levels of LYN and CFTR, reduced the infiltration of CD45<sup>+</sup>, CD8<sup>+</sup>, CD68<sup>+</sup>, and TNF-α<sup>+</sup> cells, and elevated the proportions of CD4<sup>+</sup> and CD163<sup>+</sup> cells. This evidence concerns the gene CD8A and hydrops fetalis.