Preclinically, the transferrin-targeted nanosystem Tf-LipoMof@PL increased intratumoral iron/ROS 3-5-fold, inducing robust antitumour immunity, while Ginsenoside Rh3 suppressed colorectal cancer growth in vivo via STAT3/p53/NRF2-mediated dual death induction. The gene discussed is TP53; the disease is colorectal cancer.