We critically address STAT3's paradoxical roles-promoting Gasdermin E (GSDME)-mediated pyroptosis in oesophageal cancer while suppressing NLRP3 via suppressor of cytokine signalling 3 (SOCS3) feedback in acute respiratory distress syndrome (ARDS)-highlighting cell type-specific feedback architectures that dictate phenotypic outcomes. The gene discussed is SOCS3; the disease is carcinoma of esophagus.