We sought to delineate the peripheral immunological landscape of AIP, identify its differences from PDAC and find novel biomarkers for disease differentiation.<h4>Methods</h4>Single-cell RNA/BCR sequencing (scRNA/BCR-seq) was performed on peripheral blood mononuclear cells (PBMCs) from 10 type 1 AIP patients. The gene discussed is BCR; the disease is autoimmune pancreatitis.