Finally, exercise-mediated effects and mechanisms were examined in atherosclerotic CRS-exposed mouse models and in patients with coronary artery disease (CAD) experiencing high psychological stress.<h4>Results</h4>Physical exercise alleviated stress-induced neuroimmune crosstalk, reduced the proinflammatory CD11b<sup>+</sup>Ly6C<sup>high</sup> monocyte phenotype, and suppressed M1 macrophage polarization. This evidence concerns the gene ITGAM and congenital rubella syndrome.