Although co-culturing CLL cells with γδ T cells led to decreased cell viability, CD1d and ULBP3 upregulation by healthy and CLL B cells did not elicit cytolytic degranulation or cytokine production by Vδ1, Vδ2 or Vδ3 T cells, even after presentation of CD1d-restricted lipid antigens. This evidence concerns the gene CD1D and B-cell chronic lymphocytic leukemia.