GRIN2B and anxiety disorder: EA increased IGF-1 expression in the mPFC and amygdala, and decreased NR2B, GluR2 in the amygdala (p < 0.05).<h4>Conclusion</h4>Acupuncture shows potential in treating anxiety disorders by modulating IGF-1 and NR2B expression, thus restoring neurotransmitter balance in the mPFC-amygdala pathway.