SPSS 24.0 was used for statistical analysis, including univariate analysis and binary logistic regression to screen influencing factors of splenomegaly.<h4>Results</h4>The splenomegaly group had significantly higher levels of lipoprotein(a), cholesterol, triglycerides, HbA1c, CRP, IL-6 and β2-microglobulin than the non-splenomegaly group (all <i>p</i> < 0.05). Here, IL6 is linked to Splenomegaly.