Furthermore, RT-PCR was employed to confirm their regulation pattern in relation to the NF-KB and IL-6 in various study groups, including GI=control, GII = HCV, GIII = HCV_HCC, and GIV = HCC.<h4>Results</h4>The expression levels of miR-1, miR-346, and miR-451 were significantly downregulated in GII and GIII compared with GI. The gene discussed is IL6; the disease is hepatocellular carcinoma.