Integrated multi-omics analyses-including gut microbiota profiling, untargeted metabolomics of colonic contents and serum, and lung transcriptomics-were performed to characterize treatment-associated microbial, metabolic, and transcriptional alterations.<h4>Results</h4>AEAA pretreatment dose-dependently alleviated lung injury, reduced pulmonary edema, and suppressed pro-inflammatory cytokines while restoring anti-inflammatory IL-10 levels. The gene discussed is IL10; the disease is edema.