This study explored the potential prognostic role of C-C motif chemokine ligand 3 (CCL3) and its association with immune-related signatures in COAD.<h4>Methods</h4>Multiple publicly accessible databases, including TCGA, GEPIA2, UALCAN, TIMER, and Kaplan-Meier (KM) plotter, were used to examine the expression and prognostic profiles of CCL3 in various cancers. This evidence concerns the gene CCL3 and cancer.