Furthermore, we conducted functional enrichment analyses (GO and KEGG) of genes coexpressed with CCL3, assessed methylation status using OncoBD and MEXPRESS, and developed a gene-miRNA interaction network using miRWalk to elucidate their potential roles in COAD.<h4>Results</h4>The expression of CCL3 was significantly upregulated in COAD and most other malignancies. Here, CCL3 is linked to colon adenocarcinoma.