In this study, we investigated the role of SNORA64 on an intrinsic apoptotic pathway in pancreatic cancers by using human pancreatic cell line derived from adenocarcinoma PK-8 with SNORA64 knockdown and the scramble to compare with.<h4>Methods</h4>QPCR techniques used to measure the gene expression level of apoptosis related genes and cell viability assay using trypan blue exclusion are implanted in this study as investigational methods.<h4>Results</h4>Pk-8 SNORA64 knockdown shows a significant low expression of tumor suppressor P53 in contrast to the scramble control cell line. The gene discussed is TP53; the disease is adenocarcinoma.