This study aimed to determine the frequency of anemia in patients with axSpA, assess its association with specific inflammatory markers such as the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) and evaluate the impact of anti-tumor necrosis factor (TNF)-α therapy on these parameters.<h4>Methods</h4>This study included 102 patients with axSpA. This evidence concerns the gene TNF and anemia (phenotype).