The RM1 (Ras/Myc) mouse model is a valuable tool for studying interactions between prostate tumors and the bone marrow immune landscape.<h4>Methods</h4>Single-cell RNA sequencing was employed to investigate how CCR6 deficiency affects immune cell comsmunication in bone marrow from RM1 prostate cancer bone metastasis. Here, CCR6 is linked to Familial prostate cancer.