In mouse models, CCT2 knockdown significantly enhances the antitumor efficacy of PD-1 blockade.<h4>Conclusions</h4>CCT2 stabilizes ALDOA and facilitates exosome-mediated immunosuppressive signaling, thereby linking metabolic reprogramming to immune evasion in HCC and supporting its potential as a mechanistically informed therapeutic target. The gene discussed is CCT2; the disease is hepatocellular carcinoma.