MMS22L and neoplasm: <h4>Background</h4>TONSL is involved in various biological processes such as maintaining genomic stability and promoting tumor progression.<h4>Aims</h4>The purpose of this article is to comprehensively clarify the expression of TONSL in Pan-Cancer, explore the association between TONSL expression and tumor tissues, prognosis, and immune infiltration in the tumor microenvironment, and clarify the interaction and combined effect between TONSL and MMS22L.