In multivariable analysis, urinary TCF21 remained independently associated with preeclampsia (adjusted odds ratio 2.83 per 50 pg/mL; 95% CI 1.49–5.59; p = 0.002), and combined models improved discrimination (AUC 0.87; 95% CI 0.82–0.91). This evidence concerns the gene TCF21 and preeclampsia.