Results Patients with both HTN and HBV infection (HTN+/HBV+) exhibited the most pronounced biochemical alterations, including significantly elevated liver enzymes, bilirubin, cystatin C, albuminuria, triglycerides, LDL cholesterol, and fasting glucose, along with reduced glomerular filtration rate (GFR) and potassium levels (p < 0.01). This evidence concerns the gene CST3 and hypertensive disorder.