The effect of MCB disappeared after olfactory blockade using 3-methylindole, suggesting olfactory-mediated action.<h4>Conclusion</h4>MCB enhances cognitive-olfactory functions and mitigates anxiety- and depression-like behaviors in AD mice, potentially via modulation of GSK-3β/CREB pathway-related proteins in the olfactory system. This evidence concerns the gene CREB1 and depressive disorder.