CBG glycosylation at the Asn347 site affects neutrophil elastase cleavage susceptibility, altering CBG:cortisol binding affinity, and may underlie this association.<h4>Objective</h4>This work aimed to analyze CBG Asn347 glycoforms in patients with septic shock and determine their relationship to mortality and illness severity.<h4>Methods</h4>CBG Asn347 site glycosylation profiling was performed by mass spectrometry in 128 septic shock patients from a tertiary hospital ICU at day 1 and last day of admission up to 7 days. The gene discussed is SERPINA6; the disease is septic shock.