GPT and Decreased total leukocyte count: PLD significantly reduced hematologic toxicities (leukopenia: 7.7% vs. 56.7%, <i>P</i> < 0.001) and hepatic dysfunction (alanine aminotransferase elevation: 13.4% vs. 52.8%, <i>P</i> < 0.001), with similar cardiac/pneumonia events.