<h4>Objective</h4>To investigate the association of CDK15(cyclin-dependent kinase 15) and L1CAM L1 (cell adhesion molecule) expression with clinicopathological characteristics and recurrence and/or metastasis after radical hysterectomy of cervical cancer.<h4>Methodology</h4>Retrospective analysis was performed on the clinical data of 80 patients with pathologically confirmed cervical cancer who underwent radical hysterectomy at Affiliated Hospital of Hebei University between January 2023 to January 2025. The gene discussed is CDK15; the disease is cervical cancer.