CD4 and COVID-19: PLWH who had CD4 lymphocyte counts greater than 500 cells/μL demonstrated higher NAb titers against all tested variants and reported a lower incidence of symptoms.<h4>Conclusion</h4>Hybrid immunity resulting from vaccination and BA.5/BF.7 BTI enhances humoral immune responses in PLWH, which may contribute to improved protection against COVID-19.