<h4>Background</h4>Considering the role of vitamin D in regulation of the bone metabolism and the immune system, some have suggested the effect of vitamin D receptor gene polymorphism in susceptibility to periodontitis.<h4>Purpose</h4>We aimed to determine the association between vitamin D receptor (VDR) gene polymorphisms <i>Fok1</i>, <i>Apa1</i>, <i>Bsm1</i>, and <i>Taq1</i> and periodontitis.<h4>Materials and method</h4>In this case-control study, 51 patients with stage III periodontitis (case group) and 51 without (control group) were enrolled. The gene discussed is VDR; the disease is periodontitis.