Network analysis pinpointed specific regulatory hubs, such as <i>SOX2</i> and <i>SERPINE1</i> for HPV16, and <i>ERBB4</i> and <i>GLI1</i> for HPV18, which may facilitate malignant tumor growth by disrupting metabolic, keratinization, and extracellular matrix pathways. Here, SOX2 is linked to cancer.