TF and neoplasm: We report the first dual-ligand hybrid solid lipid nanoparticle (HSLN) system for blood-brain barrier (BBB) penetration and targeted delivery of curcin, a type I ribosome-inactivating protein (RIP), to orthotopic GSM.<h4>Methods</h4>HSLNs (~150-200 nm, polydispersity index (PDI) < 0.3, zeta potential (ζ) ≈ -8 mV) were co-functionalized with transferrin and RGD peptides at optimized 4:6 ratios to enhance BBB transcytosis and tumor uptake.