The migration of RAW 264.7 macrophages was analyzed by transwell assays and the polarization was analyzed by flow cytometry.<h4>Results</h4>High-risk of MSC-related prognostic signature (PDGFB, ANPEP, CD40) was significantly linked to poor prognosis in patients under cisplatin treatment for NSCLC and other cancers. The gene discussed is CD40; the disease is cancer.