Importantly, higher predicted pTau density in the hippocampus was strongly associated with worse cognitive performance (ρ = -0.88, p = 0.0014), with a moderate association in white matter (ρ = -0.66, p = 0.036), suggesting that tau-related microstructural alterations within both gray and white matter contribute to cognitive impairment. Here, MAPT is linked to Cognitive impairment.