TRIM25 and hepatocellular carcinoma: In parallel, we investigated the regulatory effect of TRIM25 on ferroptosis in HCC cells, thereby offering experimental insights that could inform prognosis assessment and the development of targeted therapies for HCC.<h4>Methods</h4>To investigate the expression pattern of TRIM25 in hepatocellular carcinoma and its clinical relevance, we obtained RNA-seq data and corresponding clinical staging information from The Cancer Genome Atlas.