TRIM25 and hepatocellular carcinoma: The effects of TRIM25 modulation on cell proliferation and ferroptosis susceptibility were assessed using CCK-8 assays, colony formation assays, and ferroptosis-related biochemical markers.<h4>Results</h4>In the TCGA cohort, TRIM25 expression was significantly higher in HCC tissues than in adjacent normal tissues and progressively increased with advancing tumor stage.