LGI1 and encephalitis: Diagnostic delay (OR = 1.01, 95% CI 1.00-1.02, <i>p</i> = 0.037) and GTCS (OR = 5.01, 95% CI 1.11-22.66, <i>p</i> = 0.036) were independent predictors of poor prognosis.<h4>Conclusions</h4>This study suggests that early-onset and late-onset anti-LGI1 encephalitis may possess differential immunogenetic and clinical profiles.