However, a comprehensive analysis of the research landscape, evolutionary pathways, and knowledge structure in this field remains lacking.<h4>Methods</h4>Publications related to CD276/B7-H3 in cancer research were systematically retrieved from the Web of Science Core Collection (WoS, n = 688) and Scopus (n = 759) spanning from January 2001 to August 2025. The gene discussed is CD276; the disease is cancer.