Keyword evolution revealed a clear transition from early themes such as "expression" and "prognosis" to contemporary focuses including "immunotherapy," "tumor microenvironment," and "chimeric antigen receptor".<h4>Conclusion</h4>This study provides the first integrated bibliometric overview of CD276/B7-H3 research in cancer, illustrating a rapid transition from mechanistic exploration to clinical application. The gene discussed is CD276; the disease is neoplasm.