Immune-cell eQTL analysis identified an association between increased MYLK expression in dendritic cells and elevated LUAD risk.<h4>Conclusions</h4>These findings define an endothelial-centered regulatory framework in LUAD and highlight the context-dependent, cell-type-specific roles of MYLK at the tumor-endothelial-immune interface. The gene discussed is MYLK; the disease is neoplasm.