SCD and immunoglobulin G4-related sclerosing disease: In an independent validation cohort, flow cytometry was employed to detect B-cell subpopulations, lipid content, and the expression of stearoyl-CoA desaturase 1 (SCD1).<h4>Results</h4>Significant differences in metabolite profiles were observed between B cells from IgG4-RD patients and healthy controls.