However, the function and specific mechanisms of S100A10 in thyroid cancer remain poorly defined.<h4>Methods</h4>Single-cell RNA sequencing data of PTC from public databases were analyzed to screen differentially expressed genes (DEGs), among which S100A10 emerged as a potential biomarker associated with PTC metastasis and prognosis. The gene discussed is S100A10; the disease is thyroid gland carcinoma.