<h4>Objective</h4>To investigate the correlations among seven emotions, Traditional Chinese Medicine (TCM) syndromes, and serum levels of Interleukin-6 (IL-6) and Interferon-gamma (IFN-γ) in patients with primary lung cancer.<h4>Methods</h4>In this prospective cohort study, 331 newly diagnosed, treatment-naïve lung cancer patients were enrolled. This evidence concerns the gene IFNG and lung carcinoma.