Crucially, Spearman's correlation analysis revealed a significant positive correlation between the total emotion score and serum IL-6 level (rs = 0.325, p < 0.001), and a significant negative correlation with IFN-γ level (rs = -0.391, p < 0.001).<h4>Conclusion</h4>The seven emotions exhibit syndrome-specific expression patterns in lung cancer patients. This evidence concerns the gene IL6 and lung cancer.