Overexpression of Bcl-2 was associated with worse overall mortality (HR = 1.92, <i>P</i> = .002).<h4>Conclusion</h4>These findings support EGFR, cyclin D1, and Bcl-2 as biomarkers which portend worse prognosis in HNSCC. This evidence concerns the gene EGFR and head and neck squamous cell carcinoma.