In this systematic review and meta-analysis, we aim to measure the association of each protein with survival in HNSCC.<h4>Data sources</h4>PubMed, Scopus, and Cochrane databases.<h4>Review methods</h4>A systematic review of EGFR, cyclin D1, and Bcl-2 was conducted to determine the association between overexpression and survival in HNSCC. This evidence concerns the gene EGFR and head and neck squamous cell carcinoma.