Urokinase-type plasminogen activator (PLAU) has been implicated in the regulation of several liver diseases, but its role in AR remains unclear.<h4>Methods</h4>In this study, through bioinformatics analysis and transcriptome sequencing, we find that PLAU and prostaglandin-endoperoxide synthase 2 (Ptgs2) can regulate macrophage polarization. Here, PLAU is linked to liver disorder.