FCGR2B and cancer: However, hIgG1 CL was unaffected by whole body knockout of FcγRIIb.<h4>Conclusion</h4>Reduced CL of D265A versus IgG1 in LLC TB mice, but not TF mice, suggests FcγRs are involved in catabolic CL of IgG antibodies in the presence of LLC tumors and cancer cachexia.